胡泽岚  博士/副教授/硕士生导师

地址🙅🏼‍♀️：上海市徐汇区梅陇路130号实验十八楼721室

Email：huzelan@ecust.edu.cn

邮编：200237

个人简介

2004年6月毕业于第四军医大学，获医学硕士学位🖕🏼，2011年6月毕业于同济大学生命科学技术杏悦2🌞，获得生物化学与分子生物学博士学位🌕，后进入杏悦2平台药学博士后科研流动站从事博士后研究，合作导师为熊志奇教授🫵🏻。2014年7月获得博士后国际交流计划资助，在澳大利亚昆士兰大学访学，回国后加入李剑教授团队🚭，从事药理学方面的研究👨🏻‍🦰。

研究方向是抗衰老药物的研发⚉，立足团队老药新用与老药二次研发策略，利用线虫🧑‍🍳、果蝇💑、小鼠和人类细胞多种模式生物🚶🏻‍♀️‍➡️，开发抗衰老候选药物，并进行靶标确证和机制研究。近年来，本人以第一/通讯作者在Acta Pharm. Sin. B（药学1区）、Oxid Med Cell Longev.（生物学2区）🏃‍♀️、Aging-us（老年医学1区）等国内外知名学术期刊行发表多篇SCI文章，申请发明专利8项（授权2项）。

教育情况

https://doi.org/10.1016/j.apsb.2021.08.007 

2)      Liu WW, Guan, YH, Qiao SC, Wang JQ, Bao KT, Mao ZF, Liao L, Moskalev A, Jiang B, Zhu J, Xia CL*, Li J*,Hu ZL*. Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice. Oxid Med Cell Longev. 2021, 9942090. doi:10.1155/2021/9942090.

3)      Liu WW, Lin HL, Mao ZF, Zhang LX, Bao KT, Jiang B, Xia CL, Li WJ, Hu ZL*, Li J*. Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy, Aging-US. 2020, 12(6): 5300-5317.

4)      Xing SL, Zhang LX, Lin HL, Mao ZF, Bao KT, Hao P, Pei Z, Li J*, Hu ZL*. Lactose induced redox-dependent senescence and activated Nrf2 pathway. Int. J. Clin. Exp. Pathol. 2019, 12(6), 2034–2045.

5)      Chen XY, Fang MR, Xing SL, Zuo DM., Zhang P*, Hu ZL*. Osteopontin-enriched formula feeding improves the T-cell-dependent humoral immune responses in infant rats. Int J Food Sci Nutr. 2018; 1-7

6)      Liu J W, Mao L, Zhu ZC, Li K, Liao LJ, Zu Y, Liu YJ, Xiong ZQ, Hu ZL*, Zheng J*. DSTYK knockout affects the architecture of F-actin cytoskeleton in mouse renal proximal convoluted tubules. Int J Clin Exp Pathol. 2017;10(5):6157-6169.

7)      Wang HT, Zeng L, Chen Q, Zhang X, Liu JW, Lu TJ, Xiong, ZQ, Zheng, J*, Hu ZL*. Beta-Catenin is required for maintaining hippocampal morphology during the perinatal period. Neuroscience. 2014; 284C:273-282.

8)      Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, Xiong Z. Jiang H, Zheng J*, Hu ZL*. Protein Tyrosine Phosphatase U (PTPRU) is Required for Glioma Growth and Motility.  Carcinogenesis. 2014; 35(8):1901-1910.

9)      Wang HT, Zeng L, Zhang X, Li K, Zu Y, Liu JW, Liu YJ, Zhu ZC, Xiong ZQ, Zheng J*, Hu ZL*: Inactivation of beta-catenin results in the reduction of postnatal body weight gain. Brain Res Bull. 2014; 100:55-60.

10)    Shi M^#, Hu ZL^#, Zheng MH^#, Song NN, Huang Y, Zhao G, Han H, Ding YQ: Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus. J Cell Sci. 2012, 125(Pt 18): 4320-4332

11)    Hu ZL, Huang Y, Tao XR, Qi ZH, Chen JY, Ding YQ: Inducible Prrxl1-CreER(T2) recombination activity in the somatosensory afferent pathway. Genesis. 2012, 50(7): 552-560.

12)    Hu ZL^#, Shi M^#, Huang Y, Zheng MH, Pei Z, Chen JY, Han H, Ding YQ: The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev. 2011, 6:14.